Background: Novel pro-inflammatory and anti-inflammatory derivatives from adipose tissue, known as adipokines,\nact as metabolic factors. The aim of this study was to analyse the secreted expression of different adipo/cytokines\nin secretomes of unstable carotid atherosclerotic plaque versus non-atherosclerotic mammary artery.\nMethods: We evaluated the secretion levels of adiponectin, visfatin, lipocalin-2, resistin, IL-6 and TNFR2 by ELISA in\nhuman secretomes from cultured unstable carotid atherosclerotic plaque (n = 18) and non-atherosclerotic mammary\nartery (n = 13). We also measured visfatin serum levels in patients suffering from atherosclerosis and in a serum cohort\nof healthy subjects (n = 16).\nResults: We found that visfatin levels were significantly increased in unstable carotid atherosclerotic plaque\nsecretome than in non-atherosclerotic mammary artery secretome. No differences were found with regard the\nother adipo/cytokines studied. Regarding visfatin circulating levels, there were no differences between unstable\ncarotid atherosclerotic plaque and non-atherosclerotic mammary artery group. However, these visfatin levels were\nincreased in comparison to serum cohort of healthy subjects.\nConclusions: Of all the adipo/cytokines analysed, only visfatin showed increased levels in secretomes of unstable\ncarotid atherosclerotic plaque. Additional human studies are needed to clarify the possible role of visfatin as\nprognostic factor of unstable carotid atherosclerotic plaque.
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