Aims. To investigate the postprandial changes in serum lipoproteins and blood glucose and to verify whether different nutrient\r\ncomposition of the meal elicits different response in patients with (MetS) and without (MetS-) metabolic syndrome. Research\r\nDesign andMethods. 50MetS patients and 50 age- and sex-matchedMetS- consumed a regular lunch chosen among those more\r\nsimilar to their usual diet. Blood was drawn in the morning after 12-hour fasting and 2 and 4:30 hours after the meal. Results.\r\nSerum triglycerides increased more in MetS (35%, 4:30 hours after the meal) than in MetS- (29%), HDL-cholesterol decreased\r\n2 hours after the meal in both groups (-4% and -5%, resp.). Blood sugar similarly increased in both groups (19%, 2 hours\r\nafter the meal in MetS and 17% in MetS-) and plasma insulin increased more and remained high longer in MetS (73.5 and\r\n52.3 �µU/mL, 2 and 4:30 hours after the meal) than in MetS- (46.7 and 21.6 �µU/mL). Difference in nutrient composition of the\r\nmeal (carbohydrate 57%, fat 28% versus carbohydrate 45%, fat 35%) was not associated with differences in postprandial levels\r\nof triglycerides, HDL-cholesterol, glucose, and insulin within each group. Conclusions. As compared with MetS-, MetS patients\r\nshow a greater hypertriglyceridemic and hyperinsulinemic response to a regular lunch whatever the carbohydrate or fat content of\r\nthe meal.
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