Both genetic and epigenetic factors are important regulators of the immune system. There is an increasing body of evidence\r\nattesting to epigenetic modifications that influence the development of distinct innate and adaptive immune response cells.\r\nChromatin remodelling via acetylation, methylation, phosphorylation, and ubiquitination of histone proteins as well as DNA,\r\nmethylation is epigenetic mechanisms by which immune gene expression can be controlled. In this paper, we will discuss the role\r\nof epigenetics in the regulation of host immunity, with particular emphasis on histone deacetylase inhibitors. In particular, the role\r\nof HDAC inhibitors as a new class of immunomodulatory therapeutics will also be reviewed.
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