Dendritic cells (DCs) are essential components of the immune system and contribute to immune responses by activating or\r\ntolerizing T cells. DCs comprise a heterogeneous mixture of subsets that are located throughout the body and possess distinct and\r\nspecialized functions. Although numerous defined precursors from the bone marrow and spleen have been identified, emerging\r\ndata in the field suggestsmany alternative routes ofDC differentiation fromprecursorswithmultilineage potential.Here,we discuss\r\nhow the combinatorial expression of transcription factors can promote one DC lineage over another as well as the integration of\r\ncytokine signaling in this process.
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