Serotonin receptors are G-protein-coupled receptors (GPCRs) involved in a variety of psychiatric disorders. G-proteins,\nheterotrimeric complexes that couple to multiple receptors, are activated when their receptor is bound by the\nappropriate ligand. Activation triggers a cascade of further signalling events that ultimately result in cell function\nchanges. Each of the several known G-protein types can activate multiple pathways. Interestingly, since several\nG-proteins can couple to the same serotonin receptor type, receptor activation can result in induction of different\npathways. To reach a better understanding of the role, interactions and expression of G-proteins a literature search\nwas performed in order to list all the known heterotrimeric combinations and serotonin receptor complexes. Public\ndatabases were analysed to collect transcript and protein expression data relating to G-proteins in neural tissues.\nOnly a very small number of heterotrimeric combinations and G-protein-receptor complexes out of the possible\nthousands suggested by expression data analysis have been examined experimentally. In addition this has mostly\nbeen obtained using insect, hamster, rat and, to a lesser extent, human cell lines. Besides highlighting which interactions\nhave not been explored, our findings suggest additional possible interactions that should be examined based on our\nexpression data analysis.
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