The analyses of genetic factors contributing to\nAlzheimer�s disease (AD) and other dementias have evolved\nat the same pace as genetic and genomic technologies are\ndeveloped and improved. The identification of the first genes\ninvolved in AD arose from family-based studies, but risk\nfactors have mainly been identified by studies comparing\ngroups of patients with groups of controls. The best outcomes\nhave been heavily associated with the capacity of interrogating\ngenetic variability at the genome level without any particular\na priori hypothesis. In this review we assess the role of\ngenetic family studies in Alzheimer�s disease and other dementias\nwithin the current status of dementias� and, particularly,\nAD�s genetic architecture.
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