Objectives. To explore the association between meditation and health related quality of life (HRQOL), depression, fatigue, disability\nlevel, relapse rates, and disease activity in a large international sample of people withmultiple sclerosis (MS). Methods. Participants\nwere invited to take part in an online survey and answer questions relating to HRQOL, depression, fatigue, disability, relapse rates,\nand their involvement in meditation practices. Results. Statistically and potentially clinically significant differences between those\nwhomeditated once a week or more and participants who never meditated were present formeanmental health composite (MHC)\nscores, cognitive function scale, and health perception scale. The MHC results remained statistically significant on multivariate\nregression modelling when covariates were accounted for. Physical health composite (PHC) scores were higher in those that\nmeditated; however, the differences were probably not clinically significant. Among those who meditated, fewer screened positive\nfor depression, but there was no relationship with fatigue or relapse rate. Those with worsened disability levels were more likely\nto meditate. Discussion. The study reveals a significant association between meditation, lower risk of depression, and improved\nHRQOL in people with MS.
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