Background: The clinical traits of Kufs disease (KD) type B (CLN13), an adult-onset neuronal ceroid lipofuscinosis\n(NCL), are well established according to the neurological features of the cases reported with mutations in CTSF.\nThe neuroradiological characteristics of this uncommon disease have not yet been outlined.\nCase presentation: We hereby report the brain MRI features in two Caucasian women who carried homozygous\nmutations in CTSF, providing a short review of the neuroradiological findings of other common NCLs.\nTogether with a brain volume reduction, the two cases showed white matter hyperintensities and thinning of the\ncorpus callosum at onset of the cognitive decline.\nConclusion: White matter hyperintensities associated with volume reduction of the corpus callosum may be\npresent at the beginning of the behavioural changes in CLN13 and represent further clues for searching mutations\nin CTSF
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