Background. There is paucity of data on prevalence of Adverse Drug Reactions (ADRs) and adherence and clinical outcomes of\nantidepressants.Thepresent study determined themagnitude ofADRs of antidepressants and their impact on the level of adherence\nand clinical outcome. Methods. A prospective cross-sectional study was conducted among depression patients fromSeptember 2016\nto January 2017 at Gondar University Hospital psychiatry clinic. The Naranjo ADR probability scale was employed to assess the\nADRs. The rate of medication adherence was determined usingMoriskyMedication AdherenceMeasurement Scale-Eight. Results.\nTwo hundred seventeen patients participated in the study, more than half of them being males (122; 56.2%).More than one-half of\nthe subjects had low adherence to their medications (124; 57.1%) and about 186 (85.7%) of the patients encountered ADR. The most\ncommon ADR was weight gain (29; 13.2%).More than one-half (125; 57.6%) of the respondents showed improved clinical outcome.\nOptimal level of medication adherence decreased the likelihood of poor clinical outcome by 56.8%. Conclusion. ADRs were more\nprevalent. However, adherence to medications was very poor in the setup. Long duration of depression negatively affects the rate\nof adherence. In addition, adherence was found to influence the clinical outcome of depression patients.
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