Parkinson�s disease (PD), the second most\r\ncommon neurodegenerative disease, is characterized by\r\nthe progressive loss of dopaminergic neurons in the\r\nsubstantianigraparscompacta(SNpc)andtheformation\r\nof intracytoplasmic Lewy inclusion bodies. To date, the\r\ndiagnosisofidiopathicPDismainlybasedonitscardinal\r\nclinical features: resting tremor, bradykinesia and\r\nrigidity.Inrecentyears,advancesinmagneticresonance\r\nimaging (MRI), transcranial sonography (TCS) and\r\nfunctional imaging which includes positron emission\r\ntomographyPETand single photon emission\r\ncomputed tomography (SPECT) have provided new\r\ntoolsforthediagnosisofPDinitsearlystagesandhave\r\ndiscriminated it from other atypical Parkinsonian\r\nsyndromes. This review focuses mainly on the current\r\ndevelopment of neuroimaging and its application in the\r\ndiagnosisanddifferentialdiagnosisofPD.
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