Theextracellular protein Reelin was initially identified as an essential factor in the control of neuronal migration and layer formation\r\nin the developing mammalian brain. In the years following its discovery, however, it became clear that Reelin is a multifunctional\r\nprotein that controls not only the positioning of neurons in the developing brain, but also their growth, maturation, and synaptic\r\nactivity in the adult brain. In this review, we will highlight the major discoveries of the biological activities of Reelin and the\r\nunderlying molecular mechanisms that affect the development and function of the mammalian brain, from embryonic ages to\r\nadulthood.
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