Skin cancer has been shown to present asymmetrically, prevalent on the left side of the body, more so in subtypes of cutaneous\nmelanoma such as lentigo maligna. Biases have been linked to cumulative UV light exposure and auto mobile driving patterns.\nThough left-right ratios have previously correlated with the side men or women tend to position themselves or countries drive on,\nmore recent trends indicate a consistent left-sided bias. To clarify reasons for changing trends, a review of the evidence base and\nLMââ?¬â?¢s laterality in a UK cohort (99 cases 2000ââ?¬â??2011) was conducted for the first time. The strong correlation of left-sided excess,\nfound in both genders (ratios 1.381ââ?¬â??1.5, P < 0.05 X2 0.841), is congruent with more recent findings. Though evidence indicates\nthat driving position is no longer a risk factor for LM, due most likely to improved car window UV protection, it remains the most\ncommonly attributed cause. Understanding phenomena such as UV lights ââ?¬Å?scatter effectââ?¬Â or that cumulative exposure may not be\na significant risk factor helps rationalize older conclusions that would otherwise appear contradictory. The reasons for left-sided\nexcess remain unclear but may be due to factors requiring further research such as the bodyââ?¬â?¢s anatomical/embryological asymmetry.
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