Pruritus, the most common cutaneous symptom, is widely seen in many skin complaints. It is an uncomfortable feeling on the skin\nand sometimes impairs patients� quality of life. At present, the specific mechanism of pruritus still remains unclear. Antihistamines,\nwhich are usually used to relieve pruritus, ineffectively work in some patients with itching. Recent evidence has suggested that,\napart from histamine, many mediators and signaling pathways are involved in the pathogenesis of pruritus. Various therapeutic\noptions for itching correspondingly have been developed. In this review, we summarize the updated pathogenesis and therapeutic\nstrategies for pruritus.
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