Aim.To clarify the association between the single nucleotide polymorphisms (SNPs) in the NLRP1 and NLRP3 and PsoriasisVulgaris\n(PsV) in the ChineseHan population. Methods.We genotyped eight SNPs, four fromNLRP1 (rs8079034, rs11651270, rs11657747, and\nrs878329) and NLRP3 (rs7512998, rs3806265, rs10754557, and rs10733113) each in 540 patients with PsV and 612 healthy controls\nin the Chinese Han population using an improved multiplexed ligation detection reaction (iMLDR) method. The genotype and\nhaplotype frequencies were analyzed using a case-control study design. Results.We identified two SNPs, rs3806265 and rs10754557,\nin NLRP3 that were significantly associated with PsV.The genotype distribution of the rs3806265 SNP was significantly different\nbetween cases and controls (
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