Syphilis is a sexually transmitted disease caused by Treponema pallidum. The signs and symptoms of syphilis vary depending on\nwhich of the four stages it presents. The primary stage of syphilis classically presents with a painless ulcer (chancre). We report a\ncase of the extragenital chancre on the nipple which is examined from skin biopsy and immunohistochemistry. This case showed\nthat it is important to identify the special siteâ??s pruritus erythema by pathology and serological examination.
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