Background: Acral peeling skin syndrome is a rare autosomal recessive genodermatosis due to a missense\r\nmutation in transglutaminase 5. The skin peeling occurs at the separation of the stratum corneum from the\r\nstratum granulosum.\r\nCase presentation: We present a case of two siblings who developed continuous peeling of the palms and soles\r\nfrom the first year of life. This peeling was more severe on the soles than palms and on younger sibling than elder\r\nsibling. Peeling is worsened by occlusion and sweating.\r\nConclusions: Sporadic cases of Acral Peeling Skin Syndrome occur in African population. There is variability in time\r\nof presentation and clinical severity even within families.
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