Rheumatoid arthritis is a progressive chronic inflammatory disease characterized by the activation of synovial tissue lining the joint capsule, which results in the invasion of the cartilage and bone leading to the progressive joint dysfunction. Hence the herbal formulation containing guggul, haridra has been developed. Guggul and haridra which are reported to have string anti-arthritic and anti-inflammatory activity. Guggulsterone E and Z are the active principles present in the guggul extracts and responsible of the anti-arthritic activity. Haridra is also reported to have anti-inflammatory activity and curcumin is the compound provides that’s said potential to haridra. The development of a stable polyherbal formulation is a challenging task because of the large number of varied chemical compounds present in the different medicinal plants. Hence, in the present study the attempt has been made to evaluate the quality of the formulation by using high performance thin layer chromatography. In the present research we have developed the HPTLC method which is capable to identify and determine the amount of guggulesterone E, Z and curcumin.
Loading....