A simple, rapid and precise reverse phase liquid chromatographic (RP-HPLC) method was developed and subsequently validated for simultaneous estimation of glipizide and simvastatin in bulk drug and in a synthetic mixture. The analysis was carried out using standard BDS C18 (BDS 100 x 4.6 mm, 5 μm, Make: Thermo electronics), prepacked column. The separation was carried out using a mobile phase containing 0.1% ortho phosphoric acid buffer and acetonitrile (20:80 v/v), was pumped at a flow rate of 1 ml/min with PDA detection at 234 nm. Both the drugs were well resolved on the stationary phase and the retention times were around 2.357 minute for glipizide and 6.140 minute for simvastatin. The method was validated and shown to be linear for glipizide and simvastatin. The correlation coefficients for glipizide and simvastatin are 0.9997 and 0.9999 respectively.
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