A simple, accurate and precise dual wavelength UV spectrophotometric method was developed for simultaneous determination of paracetamol and metoclopramide hydrochloride in combined pharmaceutical dosage forms by using standard addition method. The literature review reveals that there was no dual wavelength method was developed for this combination of drugs, hence this method was developed. The wavelengths selected for determination of paracetamol were 266.2 nm (ƛ1) and 276.5 nm (ƛ2), whereas, the wavelengths selected for determination of metoclopramide hydrochloride were 235.4 nm (ƛ3) and 251.7 nm (ƛ4). Methanol and distilled water were used as solvents. Regression analysis of Beer’s plots showed good correlation in concentration range of 5-30 μg/ml for paracetamol and 5-30 μg/ml for metoclopramide hydrochloride. Accuracy of method was found between 98.63-99.50%. The precision (intra-day, inter-day and analyst to analyst) of method was found within limits (% CV<2). LOD was found to be 0.3 μg and 0.116 μg for paracetamol and metocloprmide hydrochloride respectively and LOQ was found to be 0.909 μg and 0.352 μg for paracetamol and metocloprmide hydrochloride respectively. The proposed method was successfully applied to determination of these drugs in laboratory-prepared mixtures and commercial tablets.
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