Five simple and cost-conscious UV spectrophotometric methods (A-E) has been developed and validated for the\ndetermination of avitriptan in bulk and pharmaceutical formulations. These methods were based on the formulation of colored\ncomplex of avitriptan with different reagents. The absorbance of the formed color complex was measured at the wavelength of\nmaximum absorbance of the complex against the reagent blank. Method A and B were based on the formation of colored species\nbetween the avitriptan and TPooo and ARS by means of ion association complex formation reaction. The absorbance was\nmeasured at max = 560 for method A and max = 590 for method B. Method C was based on the reaction of avitriptan with folin to\nform a blue colored species having absorption maxima at max = 450 nm. Method D was based on the formation of diazotization\ncoupling of drug with PNA a colored species was found and exhibit absorption maxima at max = 470 nm. Method E was based on\noxidation followed by complex formation with 2,2�- bipyridyl in the presence of ferric chloride having absorption maxima at max\n= 400 nm. All these methods have different linearity ranges. Statistical analysis proves that the proposed methods were\nreproducible and selective for the estimation of avitriptan in bulk drug and in its tablet dosage form.
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