The present work deals with development of two rapid, precise and accurate spectrophotometric methods for the estimation of dexchlorpheniramine maleate in bulk and solid dosage form. Method A is absorption maxima method in which λmax was 260 nm. Method B is area under the curve in which wavelength range 248-272 nm was selected for estimation of dexchlorpheniramine maleate. Linearity was observed in the concentration range 10-90 µg/ml for both the methods (r2 = 0.9996 for method A and r2 = 0.9997 for method B). The results of analysis have been validated statistically, which confirm the accuracy and reproducibility of the methods. All the methods were found to be simple, precise and accurate and can be employed for routine quality control analysis of dexchlorpheniramine maleate in bulk as well as in its solid dosage form.
Loading....