Two UV methods were developed for combined formulation of indapamide and olmesartan medoxomil. First method is simultaneous equation method. In this method the absorbance at 240 nm and 256 nm were used for IND and OLM respectively. Second method is first order derivative spectroscopic method. In second method the absorbance at 225.4 nm (Zero crossing point of IND) and 256.6 nm (Zero crossing point of OLM) were used for estimation of OLM and IND respectively. In both methods linearity was taken in the concentration series of 1-30 μg/ml for IND and 10-70 μg/ml for OLM. The developed methods were validated as per ICH guidelines.
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