Zolmitriptan (ZMT) is a 5-HT 1B/1D receptor partial agonist which has been approved for use in the acute treatment of migraine. A simple, precise, accurate and economical UV-Spectrophotometric method has been developed for the determination of ZMT in bulk and pharmaceutical dosage form. The absorbance for ZMT was measured at maximum wavelength of 281 nm. The percentage recovery of ZMT in pharmaceutical dosage form was found to be 99.97±0.3969. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. Beers law was obeyed in the concentration range of 5-50 μg/ml having line equation y = 0.019x with correlation coefficient of 0.998. Results of the analysis were validated according to the ICH guidelines. The results obtained were statistically evaluated and were found to be accurate and reproducible. The proposed method can be successfully applied for the estimation of ZMT in bulk and pharmaceutical dosage form.
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