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Inventi Impact: Pharm Analysis & Quality Assurance

Articles

  • Inventi:ppaqa/20924/16
    Simultaneous Estimation of Mefenamic Acid and Tizanidine in\nTablet Dosage Form by Dual Wavelength Method
    15-Apr-2017 Research 2017 : April - June
    Ghanshyam G Solanki *, Lalit Lata Jha, Falguni B Tandel, Lalcheta Sagar

    In the present work one simple and sensitive UV spectrophotometric method have been developed for the\nquantitative estimation of mefenamic acid and tizanidine hydrochloride in combination. For this dual wavelength method, 222\nnm and 237 nm were selected as �»1 and �»2 for the determination of mefenamic acid and 240 nm and 272 nm were selected as �»3\nand �»4 for the determination of tizanidine hydrochloride. The method was validated with respect to linearity, precision,\naccuracy, LOD and LOQ with analytical method validation guideline. Linearity was observed in the concentration range of 0.64-\n3.84 �¼g/ml for mefenamic acid and 1-6 �¼g/ml for tizanidine hydrochloride. The % recovery of mefenamic acid and tizanidine\nhydrochloride was found to be 98.87�±0.0143 - 101.4�±0.0213. The % RSD for intraday precision and interday precision were\nfound to be less than 2 which confirms that the method was precise.

    How to Cite this Article
    Ghanshyam G Solanki, Lalit Lata Jha,\nFalguni B Tandel et al. Simultaneous Estimation of\nMefenamic Acid and Tizanidine in Tablet Dosage Form\nby Dual Wavelength Method. Inventi Impact: Pharm\nAnalysis & Quality Assurance, 2017(2):39-42, 2017.
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