In the present study bilayered tablet coating of two drugs were prepared which are complimentary of each other. One is glyburide which was used for quick release and the other is Metformin Hydrochloride which was used for sustained release using super disintegrant property of sodium starch glycolate for latter and matrix forming agents like Hydroxyl Propyl Methyl Cellulose (HPMC K 4) and Sodium Carboxy ethyl Cellulose (SCMC) and binder like PVPK-30 for former. All the tablets were evaluated for their physicochemical properties and were found within satisfactory region. Regression coefficient method was used for evaluation of the release kinetics of Metformin HCl. Various formulations were made so as to get a good release profile out of which only one (F4) showed zero order release in which dominant mechanism was diffusion. Because of the significant effect of the polymers which were used it was possible to attain quick release of glyburide and sustain release of Metformin hydrochloride over a period of approximately 8 hours.
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