A study was carried out to investigate compatibility of amlodipine besylate and olmesartan medoxomil with a variety of\npharmaceutical excipients. Both drugs are antihypertensive agents that can be administered alone, in monotherapy, or in\npharmaceutical association. The studies were performed using binary and ternary mixtures, and samples were stored for 3 and 6\nmonths at 40Ã?°C under 75% relative humidity and dry conditions. For this study, a method based on high-performance liquid\nchromatography (HPLC) was developed and validated for the simultaneous determination of amlodipine besylate and olmesartan\nmedoxomil in samples from pharmaceutical preformulation studies using diode array detector (DAD) and charged aerosol\ndetector (CAD). The runtime per sample was 10 min with retention time of 7.926 min and 4.408 min for amlodipine and\nolmesartan, respectively. The validation was performed according to ICH guidelines. The calibration curve presents linear\ndynamic range from 12 to 250 Ã?¼g mLâË?â??1 for amlodipine and from 25 to 500 Ã?¼g mLâË?â??1 for olmesartan with coefficient of determination\n(R2 ââ?°Â¥ 0.9908) while repeatability and reproducibility (expressed as relative standard deviation) were lower than 1.0%.\nThe excipients such as corn starch, croscarmellose sodium, magnesium stearate, polyvinyl alcohol, talc, polyvinylpyrrolidone,\nlactose monohydrate, and polyethylene glycol showed potential incompatibilities after accelerated stability testing
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