Alzheimer’s disease (AD) progresses due to beta amyloid aggregation and decreased acetylcholine level. Amyloid-β peptide (Aβ) formed by the continuous proteolytic processing of β-amyloid precursor protein (β APP) by β-secretase (BACE1) and γ-secretase (BACE2), plays a vital role in the pathogenesis of alzheimer’s disease (AD). Evaluated dipeptides and octapeptides exhibit inhibitory action against betasecretase enzyme. In-vitro enzyme inhibition assay was carried out for betasecretase enzyme and the IC50 value of DP I was found to be 0.0098 μg/ml and the standard donepezil (AChE inhibitor) was found to be 0.065 μg/ml. Based on the results the dipeptides and octapeptides were highly potent inhibition than control.
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