Two simple, economical, precise and reproducible visible spectrophotometric methods have been developed for the estimation of Dicycloverine Hydrochloride. The developed methods are based on the formation of chloroform extractable complex of Dicycloverine hydrochloride with bromo phenol blue and phenol red. The complex with bromo phenol blue (method I) shows absorbance maxima at 387.4 nm and linearity in the concentration range of 10-60 µg/ml. The extracted complex with phenol red (Method II) shows absorbance maxima at 373.4 nm and the linearity in the concentration range of 10-80 µg/ml. Results of analysis for both the methods were validated statistically and by recovery studies. These methods were successively applied to pharmaceutical formulation because no interferences from tablet excipients were found. The suitability of these methods for the quantitative determination of the compounds was proved by validation.
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