Simple, sensitive and specific Chromatographic method was developed and validated for simultaneous estimation of Diacerein (DIA) and Aceclofenac (ACE) in tablet dosage form. The new analytical method was developed based on the simultaneous estimation of drugs in a binary mixture without previous separation. In graphical vierordt’s method was performed by absorbance at 254.0nm and 298.0nm. Both the drug DIA and ACE and its mixture follow beer-lamber’s law in the range of 2 -10 μg/ml at the entire selected wavelengths. The percent estimation of mix drug in laboratory mixture was done to be 100.57 + 0.64 and 99.55 + 1.74 for DIA and ACE respectively. The percent drug estimation in marketed formulation was found to be 100.82+ 0.91 and 99.61 +1.46 the average percent recovery was found to be 99.28 +1.30 and 98.54+0.56. The result of the method lies within the prescribe limit of 98-102% shows that method is free from interference from excipients.
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