These days Slimming Herbal Medicinal Products (HMPs) are more in demand in Indian market and it encourages manufacture of Slimming HMPs to be adulterate the HMPs with active Synthetics to increase the efficiency of the products. Sibutramine is anorexic drug by acting on serotonin neurotransmitter. But Sibutramine is the drug which is recently banned due to few life threatening cardiac side effects. Sibutramine is one of the possible adulterant of the Slimming HMPs that can be added by the manufacturer and has to be detected by the analyst to determine the adulteration in the HMPs. The purpose of this study was to identify and quantify the Sibutramine in the Slimming HMPs in less time with accurate result. The new validated method was developed by HPTLC at 223 nm. HPTLC separation was performed on (10 X10 cm, 20 X 10 cm) Pracoated Silica Gel G60 F254 Aluminum sheets by using mobile phase Chloroform: Acetone: Methanol (8.5:1.0:0.55 v/v/v). In analysis linearity in the range of 300-2500 ng/band-1 and method was validated for accuracy, precision, Linearity, Specificity, Robustness and were successfully applied to the local marketed products. As a conclusion this method was found to be useful for the routine analysis of illegally added Sibutramine in the HMPs.
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