Two simple, sensitive and accurate methods have been developed for the quantitative analysis of prulifloxacin in its pure and pharmaceutical formulations. The proposed methods were based on formation of a yellow coloured drug-dye complex that has resulted from the reaction of prulifloxacin and bromothymol blue (method-I) and the formation of blue coloured complex resulting from the reaction of prulifloxacin with 4, 7-diphenyl-1, 10-phenanthroline (Method-II). These methods have showed the absorption maximum at 420nm and 600nm for method-I and method-II respectively. The proposed methods showed good linearity in the concentration range of 5-25 µg/ml (method-I) and 2-10 µg/ml (method-II). The results of analysis for the proposed methods were validated statistically by recovery studies.
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