A rapid, simple, precise stability indicating RP-HPLC method has been developed for the estimation of Naftopidil on Phenomenex Luna C8 (4.6x150mm,5μ) .A mobile phase consisiting of Methanol : water (90:10 %v/v) was used. The flow rate was 0.8 ml/min with UV detection at 232 nm. Naftopidil was subjected to stress conditions of hydrolysis (acid, base), oxidation, photolysis and thermal degradations. Beer’s law was obeyed in the concentration range of 1-5 µg/ml and correlation coefficient as 0.9999. This method can be used for the routine analysis of naftopidil in tablet dosage form.
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