A reverse phase high performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of atorvastatin and ramipril in marketed formulation is developed. The determination was carried out on a HIQ SII C18 column -10 (4.5 mm x 250 mm).column using a mobile phase of acetonitrile: 0.02 M Potassium dihydrogen phosphate (pH 3.2) [75: 25%v/v]. The flow rate was 1 ml/min with detection at 217 nm. The Valsartan is used as internal standard in this method. The retention time for atorvastatin was 6.1 min, for ramipril 3.43 min. Atorvastatin and ramipril showed a linear response in the concentration range of 20-180 μg/ml and 10-90 μg/ml respectively. The correlation co-efficient (‘r’ value) for atorvastatin and ramipril was 0.9999 for both drugs. The results of analysis have been validated statistically and by recovery studies. The percentage recoveries obtained for atorvastatin and ramipril ranges from 99.04 to 101.15 %.
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