A simple, economical, precise and reproducible visible spectrophotometric method have been developed for the estimation of Gemifloxacin mesylate(GEM) and Ambroxol hydrochloride(AMB) from its tablet dosage form. First order derivative spectroscopy methods adopted to eliminate spectral interference. Beer’s law was obeyed in the range of 2 to 12 μg/ml for AMB and 10-60 μg/ml for GEM; wavelengths selected for Quantitation are 291nm and 244 nm respectively which are the λmax of both the drugs. The proposed methods was validated statistically and applied successfully to determination of Gemifloxacin mesylate and Ambroxol hydrochloride in bulk and tablet formulation.
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