The present investigation deals with the development of a new, simple, specific, sensitive, rapid and economical procedure for simultaneous estimation of Dexibuprofen and Paracetamol in bulk and its dosage form. The method is based on the ultraviolet absorbance maxima of the above drugs at 221.5 nm and 246nm wave lengths. These drugs obeyed Beer's Lambert law in the concentration range of 2-14 μg/ml with methanol and phosphate buffer pH 7.4 in 1:1 ratio. The correlation coefficient was 0.9985 and 0.9992 respectively. The proposed method was successfully applied for the simultaneous determination of drug in commercial tablet preparations. The precision and accuracy of the developed method was confirmed by repeatability and recovery studies validated statistically. The LOD of these drugs were found to be 0.0215 and 0.0540 respectively. The LOQ was found to be 0.0651 and 0.1638 for both drugs. The percentage recovery study of the drug for proposed method was found to be in the range of 98.64 – 101.51% w/v for branded drug. The proposed method is recommended for routine analysis since it is rapid, simple, accurate and also sensitive
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