A simple, specific, accurate and stability-indicating reversed phase high performance liquid chromatographic method was developed for the determination of Piracetam, using C18 column and a mobile phase composed of Phosphate Buffer: Acetonitrile (95:5, v/v), pH 7.0. The retention time of Piracetam was found to be 7.8 min. Linearity was established for Piracetam in the range of 100-200 μg/ml. The percentage recovery of Piracetam was found to be in the range of 98.02-98.70%. The drug was subjected to acid, alkali, oxidation, dry heat and UV degradation. The degradation studies indicated Piracetam showed degradation in base. The degradation product of Piracetam in basic condition was well resolved from the pure drug with significant differences in their retention time values. This method can be successfully employed for quantitative analysis of Piracetam in bulk drug and formulation.
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