The present manuscript describes simple, sensitive, rapid, accurate, precise and economical spectrophotometric method for the simultaneous determination of Mefenamic acid and Tizanidine in their combined dosage form. The method was based on and solving simultaneous equations for analysis of two the drugs using methanol as solvent. In this method, the absorbance was measured at 289 nm for Mefenamic acid and 318 nm for Tizanidine. The linearity was found to be in the concentration range of 8-28 μg/ml and 2-22 μg/ml for Mefenamic acid and Tizanidine respectively. Recovery studies confirmed the accuracy of proposed method and results were validated as per ICH guidelines. The method can be used for routine quality control of pharmaceutical formulation containing Mefenamic acid and Tizanidine.
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