A simple and sensitive HPTLC method has been developed for determination of Fosinopril Sodium in its pharmaceutical dosage forms. Stationary phase was Silica gel G60 F254 pre-coated on aluminum sheet and mobile phase consisting of Tetra hydro furan: Hexane: NH3 (5:5:0.5 v/v) was used. The detection of spot was carried out at 215 nm. The Rf value was found to be 0.37±0.02. The methods were validated in terms of linearity, accuracy and precision. The linearity curve was found to be linear over 1000-6000 ng/spot. The method was found to be accurate over 100.29% –100.50%. The LOD and LOQ were found to be 210 and 636 ng/spot respectively. The proposed method was validated by determining its sensitivity, accuracy and precision which proves suitability of the developed method for the routine estimation of Fosinopril Sodium in solid dosage form and applied successfully for the analysis of the drug in its tablets dosage forms.
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