The present work describes a validated reverse phase high performance liquid chromatographic method for simultaneous estimation of Spironolactone and Torsemide in tablet dosage form. The separations were achieved using Inertsil C8 column, 10µm, {250 × 4.6 mm (i.d.)} with a mobile phase consisting of Methanol: Acetonitrile: 0.05M NaH2PO4 buffer, (40:30:30%v/v/v)) pH 7.1 is adjusted with triethylamine, at the flow rate of 1ml/min, detection was carried at 257nm using a variable wavelength UV-1575 detector. The retention time for Torsemide was about 3.67 minutes and for Spironolactone was about 6.56 minutes. The linearity for Torsemide 02-20 g/ml and Spironolactone in the range of 10-100 µg/ml, respectively. The Proposed method was found to be accurate, precise, simple, specific and rapid can be used for simultaneous estimation of Spironolactone and Torsemide in tablet formulation.
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