Ultra Performance Liquid Chromatography (UPLC) is a relatively new technique giving new possibilities in liquid chromatography, especially concerning decrease of time and solvent consumption. UPLC Chromatographic system is designed in a special way to withstand high system back-pressures. Special analytical columns UPLC BEH C18 packed with 1.7 μm particles are used in connection with this system. The quality control analyses of various pharmaceutical formulations are transferred from HPLC to UPLC system. The UPLC system allows shortening analysis time up to nine times and three times comparing to the conventional system using 5 μm and 3 μm particle packed analytical columns respectively. ACQUITY Ultra Performance LC Systems take advantage of technological strides made in particle chemistry performance, system optimization, detector design, and data processing and control. When taken together, these achievements have created a step-function improvement in chromatographic performance. Defined as UPLC, this new category of analytical separation science retains the practicality and principles of HPLC while increasing the overall interlaced attributes of speed, sensitivity, and resolution.
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