Two simple, precise and cost effective spectrophotometric methods have been developed for the estimation of Sertaconazole nitrate in bulk and its pharmaceutical formulations. Method A is based on calculation of Area under Curve (AUC) for analysis of Sertaconazole nitrate in the wavelength range of 252.0 – 268.0 nm. Method B first order derivative spectroscopic method in which the wavelength selected 221nm. In both the Methods drug shows linearity in the concentration range of 10-50 μg/ml. Results of analysis for both the methods were validated statistically and by recovery studies. The proposed methods are found to be free from interference of excipients and are successfully applied to estimation of the amount of Sertaconazole nitrate in bulk and pharmaceutical dosage forms.
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