Stability is defined as the capacity of a drug substance or drug product to remain within the established specifications to maintain its identity, strength, quality and purity through out the retest or expiration dating period. Any physical, chemical or microbiological change in the product potentially impact the efficiency and integrity of the final product and may therefore directly or indirectly impact patients’ health. To investigate potential stability issues of the drug in muzox tablet, accelerated and intermediated stability studies were carried out according to ICH guidelines at 300C+20C/65%RH+ 5%RH and 400C+20C/75%RH+5%RH for six month. Stability studies were carried out using programmable environmental test chamber CHM-10s, serial no. ICH-2530 and ICH 2531 (remi instrument ltd, Mumbai) and assay was carried out by using HPLC (Jasco) method which has been developed previously. The stability testing of muzox tablets showed there was no significance change in the content of Tramadol hydrochloride and Chlorzoxazone after 6 month of storage under controlled of temperature and humidity, at 300C+20C/65%RH+5%RH. Accelerated conditions under 400C+20C/75%RH+5%RH, dosage forms exhibit slight but insignificant fall within assay value. The parameters such as appearance, hardness, friability, disintegration time periods were determined at regular interval of each month for total period of six months. It showed that there was no change in physical parameter for six months at stored condition. Periods for electrical cut off and other related problems were compensated by extending the study for the relevant periods.
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