A simple, sensitive, linear, precise and accurate RP-HPLC method for the simultaneous estimation of olmesartan medomoxil and cilindipine in bulk and tablet formulation was developed and validated. The chromatographic separation of the two drugs was achieved on eclipse XBD, C18 column (150 mm 4.6 mm i.d; particle size-5 micron) in a gradient mode. The mobile phase consisting of 0.01 M KH2PO4 buffer whose pH was adjusted to 3.0 using dilute ortho phosphoric acid (solvent A): acetonitrile (solvent B) was set with gradient programming for 15 min and was delivered at a flow rate of 1 ml/ min and effluents were monitored at 240 nm. The retention time of olmesartan medomoxil and cilindipine was found to be 5.32 and 7.16 min, respectively. Calibration curves were linear with a correlation coefficient of 0.9999 for both the drugs over the concentration range of 600-1800 µg/ml for OLM and 300-900 µg/ml for CIL and precise with (%RSD<2). The method was validated as per the ICH guidelines and can be employed for routine quality control analysis.
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