A simple, efficient, precise and accurate method have been developed for the estimation of carvedilol and lisinopril in synthetic binary mixture. In this 1st order derivative spectroscopic method UV spectrum of carvedilol and lisinopril have λmax at 283.71 and 205.8 and their ZCP are at 222.83 and 286.8 nm respectively. Methanol is used as a solvent. Both the drugs obeyed beer's law in the concentration range 5–25 μg/ml and 5–25 μg/ml for carvedilol and lisinopril respectively. The accuracy of the method was determined by recovery studies and was found to be 99.53±0.31% and 99.15±0.47% for carvedilol and lisinopril respectively. The method was validated as per ICH guidelines and statically. The method showed good reproducibility and recovery with % RSD less than 2. The method was found to be simple, economic, accurate and reproducible and can be used for routine analysis of Carvedilol and Lisinopril in pure and in fixed dose combination.
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