Background: The existing literature contains no information regarding inflammatory cytokine expression in\nunilateral acute primary angle-closure (APAC) affected eyes and fellow eyes with primary angle closure suspect\n(PACS). To measure levels of various inflammatory cytokines in the aqueous humor (AH) of APAC affected eyes and\nfellow eyes with a diagnosis of PACS (18 unilateral APAC eyes and 18 fellow eyes with PACS), and determine the\nunderlying correlation between them.\nMethods: The total levels of 12 cytokines including granulocyte colony-stimulating factor (G-CSF), interleukin (IL)-6,\nIL-8, monocyte chemotactic protein (MCP)-1, MCP-3, macrophage-derived chemokine (MDC), macrophage\ninflammatory protein (MIP)-1�², and vascular endothelial growth factor (VEGF) etc. were assessed using the multiplex\nbead immunoassay technique. The level of cytokines in different groups was analyzed by a 2-related-samples\nnonparametric test. Data on patient demographics, preoperative intraocular pressure (IOP), number of glaucoma\nmedications, as well as several ocular biological parameters were also collected for correlation analysis.\nResults: The APAC patients had significantly higher levels of G-CSF, IL-6, IL-8, MCP-1, MCP-3, MDC, MIP-1�², and\nVEGF in the AH samples from unilateral APAC affected eyes than in fellow eyes with PACS (all P < 0.05). The\ncytokines showed positive correlations between each other (P < 0.0071).\nConclusions: Cytokine networks in the AH may have critical roles in the progression of APAC. Thus, different\ncytokine expression in both eyes of the same patient may help us to understand the different pathology in APAC\nand PACS.
Loading....