Background: Colour Doppler analysis of ophthalmic vessels has been proposed as a promising tool in the diagnosis\nof various eye diseases, but the available diagnostic evidence has not yet been assessed systematically. We\nperformed a comprehensive systematic review of the literature on the diagnostic properties of Colour\nDoppler imaging (CDI) assessing ophthalmic vessels and provide an inventory of the available evidence.\nMethods: Eligible papers were searched electronically in (Pre) Medline, Embase and Scopus, and via crosschecking\nof reference lists. The minimum requirement to be included was the availability of original data\nand the possibility to construct a two-by-two table. Study selection, critical appraisal using the QUADAS II\ninstrument and extraction of salient study characteristics was made in duplicate. Sensitivity and specificity\nwas computed for each study.\nResults: We included 11 studies (15 two-by-two tables) of moderate methodological quality enrolling 820\nparticipants (range 30 to 118). In 44.4% participants were female (range 37ââ?¬â??59% in specific subgroups). CDI\nwas assessed for internal carotid stenosis, diabetic retinopathy, glaucoma, and branch or central retinal vein\nocclusion diagnosis. There was insufficient data to pool the results for specific illnesses. For the assessments\nof ophthalmic arteries, mean sensitivity was 0.69 (range 0.27ââ?¬â??0.96) with a corresponding mean specificity of 0.\n83 (range 0.70ââ?¬â??0.96). Mean sensitivity of the central retinal artery assessments was 0.58 (range 0.31ââ?¬â??0.84) and\nthe corresponding mean specificity was 0.82 (range 0.63ââ?¬â??0.94).\nConclusions: Robust assessments of the diagnostic value of colour Doppler analysis remain uncommon,\nlimiting the possibilities to extrapolate its true potential for clinical practice.\nPROSPERO 2014:CRD42014014027.
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