Background: To identify success predictors and to study the role of the fellow untreated eye as a co-variable for\nadjustment of intraocular pressure (IOP) outcomes following selective laser trabeculoplasty (SLT) in early open-angle\nglaucoma (OAG) patients.\nMethods: A case series was carried out. Patients with uncontrolled early OAG or ocular hypertension (inadequate\nIOP control requiring additional treatment) underwent SLT (one single laser session) performed by the same\nsurgeon in a standardized fashion. The same preoperative medical regimen was maintained during follow-up\nfor all patients. Post-treatment assessments were scheduled at week 1 and months 1, 2, and 3. In order to\naccount for possible influence of IOP fluctuation on laser outcomes, post-laser IOP values of the treated eye of each\npatient were also analyzed adjusting for IOP changes (between visits variation) of the untreated fellow eye (adjusted\nanalysis). Pre and post-laser IOP values were compared using paired t-test. Factors associated with the magnitude of\nIOP reduction were investigated using multiple regression analysis.\nResults: A total of 45 eyes of 45 patients were enrolled. Mean IOP was reduced from 20.8 Ã?± 5.1 to 14.9 Ã?± 2.\n9 mmHg at month 3 (p < 0.001). Adjusted success rate (defined as IOP reduction ââ?°Â¥ 20%) was 64% and mean\npercentage of IOP reduction was 23.1 Ã?± 14.3% at last follow-up visit. Considering unadjusted post-laser IOP\nvalues, it was found a 20% greater absolute IOP reduction (median [interquartile range] 6 mmHg [4ââ?¬â??7] vs\n5 mmHg [3ââ?¬â??7]; p = 0.04), with a success rate of 76%. Although baseline IOP was significantly associated with\nboth adjusted and unadjusted post-laser IOP reduction, a stronger association was found when unadjusted\nIOP values were considered (p < 0.001 and R2 = 0.35; p < 0.001 and R2 = 0.67, respectively). Age, mean deviation\n(MD) index, central corneal thickness and type of glaucoma were not significant predictors (p ââ?°Â¥ 0.150).\nConclusions: In this group of patients with early OAG or ocular hypertension, our short-term results confirmed SLT\nas a safe and effective alternative for IOP reduction. Although better outcomes were found in eyes with\nhigher preoperative IOP, this effect was mitigated when results were adjusted to the fellow untreated eye\n(to the influence of between visits-IOP fluctuations).
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