Purpose. To observe the relationship between topographic hemoglobin levels in the optic nerve head (ONH), the rim thickness\n(BMO-MRW), and retinal nerve fiber layer (RNFL) thickness. Methods. 96 normal eyes and 82 glaucomas were examined using\nTOP strategy (Octopus 300 perimeter), SPECTRALIS OCT, and Laguna ONhE program which estimates hemoglobin from\nconventional color photographs (Horus Scope DEC 200 fundus camera). Results. The correlation between Laguna ONhE\nglaucoma discriminant function (GDF) and SPECTRALIS BMO-MRW was R = 0 81 (P < 0 0001), similar to that between the\nBMO-MRW and BMO-RNFL thicknesses (R = 0 85, P < 0 0001) (P = 0 227 between both R values). GDF correlated well with\nRNFL thicknesses in the 360 degrees around the nerve, similar to mean perimetric sensitivity (MS) and BMO-MRW. The\namount of hemoglobin in the nasal and temporal sectors showed low correlation with superior and inferior RNFL thicknesses.\nThe superotemporal and inferotemporal sectors located on the vertical diameter of the disk showed good intercorrelation but\nwithout a clear RNFL topographic relationship. Conclusion. GDF showed high correlation with RNFL thickness. Except in the\nnasal and temporal sectors, ONH hemoglobin correlated well with RNFL thickness.
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