Background: To measure the microcirculation change of macula and optic nerve head before and after\nfemtosecond laser assisted laser in situ keratomileusis.\nMethods: In total 45 eyes from 45 subjects, who underwent FS-LASIK during June 2017 to December 2017 in\nGuangdong Provincial Peopleâ??s Hospital, were recruited in this study. Vessel density in macula and optic nerve head\nwere measured by optical coherence tomography angiography before and after transient elevation in intraocular\npressure caused by application of suction ring during surgery.\nResults: Vessel density (VD) at superficial (SCP) plexus of macular region did not differ after surgery (F(3,132) = 1.41,\nP = 0.24), while the deep (DCP) plexus of macular region significantly decreased 1 day after surgery (P = 0.001) but\nreturned to its baseline value 1 month postoperatively (P = 0.1). Vessel density of optic nerve head region had no\nsignificant changes after surgery (F(2.51,95.18) = 0.6, P = 0.59).\nConclusions: A short-term temporary decrease of vessel density at deep layer of macular region was observed in\neyes undergoing FS-LASIK. However, the retinal capillary density went back to preoperative level 1 month after\nsurgery. Therefore, transient IOP spike during FS-LASIK did not cause long-term decline of retinal microcirculation.
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