Endometriosis, PCOS, and unexplained infertility are currently the most common diseases rendering large numbers of women\ninfertile worldwide. Oxidative stress, due to its deleterious effects on proteins and nucleic acids, is postulated to be the one of the\nimportant mechanistic pathways in differential expression of proteins and in these diseases. The emerging field of proteomics has\nallowed identification of proteins involved in cell cycle, as antioxidants, extracellularmatrix (ECM), cytoskeleton, and their linkage\nto oxidative stress in female infertility related diseases. The aim of this paper is to assess the association of oxidative stress and\nprotein expression in the reproductive microenvironments such as endometrial fluid, peritoneal fluid, and follicular fluid, as well\nas reproductive tissues and serum. The review also highlights the literature that proposes the use of the fertility related proteins\nas potential biomarkers for noninvasive and early diagnosis of the aforementioned diseases rather than utilizing the more invasive\nmethods used currently. The review will highlight the power of proteomic profiles identified in infertility related disease conditions\nand their linkage with underlying oxidative stress. The power of proteomics will be reviewed with regard to eliciting molecular\nmechanisms for early detection and management of these infertility related conditions
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